Peer-Reviewed Journal Details
Mandatory Fields
Abbah, SA,Delgado, LM,Azeem, A,Fuller, K,Shologu, N,Keeney, M,Biggs, MJ,Pandit, A,Zeugolis, DI
2015
November
Advanced Healthcare Materials
Harnessing Hierarchical Nano- and Micro-Fabrication Technologies for Musculoskeletal Tissue Engineering
Published
Altmetric: 3WOS: 31 ()
Optional Fields
ELECTROCHEMICALLY ALIGNED COLLAGEN MESENCHYMAL STEM-CELLS GROWTH-FACTOR SUPPLEMENTATION GUIDED BONE REGENERATION MARROW STROMAL CELLS IN-VIVO PORE STRUCTURE OSTEOGENIC DIFFERENTIATION ACHILLES-TENDON GAG SCAFFOLDS
4
2488
2499
Cells within a tissue are able to perceive, interpret and respond to the biophysical, biomechanical, and biochemical properties of the 3D extracellular matrix environment in which they reside. Such stimuli regulate cell adhesion, metabolic state, proliferation, migration, fate and lineage commitment, and ultimately, tissue morphogenesis and function. Current scaffold fabrication strategies in musculoskeletal tissue engineering seek to mimic the sophistication and comprehensiveness of nature to develop hierarchically assembled 3D implantable devices of different geometric dimensions (nano-to macrometric scales) that will offer control over cellular functions and ultimately achieve functional regeneration. Herein, advances and shortfalls of bottom-up (self-assembly, freeze-drying, rapid prototype, electrospinning) and top-down (imprinting) scaffold fabrication approaches, specific to musculoskeletal tissue engineering, are discussed and critically assessed.
10.1002/adhm.201500004
Grant Details
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