Peer-Reviewed Journal Details
Mandatory Fields
Zhou, J,Matos, MC,Murphy, PV
2011
November
Organic Letters
Synthesis of a Benzomacrolactone-Based Somatostatin Mimetic
Published
()
Optional Fields
CATALYTIC DIAZOTRANSFER D-GLUCOSE EFFICIENT CHEMISTRY METATHESIS SCAFFOLDS ACID PEPTIDOMIMETICS AFFINITIES ANTAGONIST
13
5716
5719
The benzomacrolactone is a framework found in numerous natural products. The synthesis of an orthogonally functionalized benzomacrolactone from D-glucosamine and a salicylic acid derivative is described. This macrolactone was used for the synthesis of a somatostatin mimetic that has submicromolar affinity for the human somatostatin receptor 4 (hSSTR4).
DOI 10.1021/ol202528k
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