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Costelloe, T,Lowndes, NF,Nasheuer, HP
2010
October
Genome Stability And Human Diseases
Chromatin Assembly and Signalling the End of DNA Repair Requires Acetylation of Histone H3 on Lysine 56
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Chromatin Histories Acetylation H3K56 DNA repair Genome stability DOUBLE-STRAND BREAKS NUCLEOSOME CORE PARTICLE S-PHASE DAMAGE RESPONSE CELL-CYCLE SACCHAROMYCES-CEREVISIAE ANGSTROM RESOLUTION CHECKPOINT YEAST REPLICATION
50
43
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The packaging of DNA into chromatin results in a barrier to all DNA transactions. To facilitate transcription, replication and repair historic proteins are frequently post-translational modified. Such covalent additions to historic residues can modulate chromatin folding and/or provide specificity to docking surfaces for non-histone chromatin proteins. In the budding yeast, one such modification, transient acetylation Of historic H3 on residue lysine 56 (H3K56ac), occurs on newly synthesized H3 molecules and facilitates their deposition onto newly replicated DNA during S phase. H3K56ac also has a role in chromatin reassembly following DNA damage in S phase. Importantly, the completion of H3K56ac-dependent chromatin reassembly appears to be required for resumption of cell proliferation after DNA repair. Emerging evidence, although not without conflict, suggests that H3K56ac is not only present in human cells, but is similarly regulated and required for chromatin reassembly.
10.1007/978-90-481-3471-7_3
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