Peer-Reviewed Journal Details
Mandatory Fields
Drummond, FJ,Barrett, E,Burns, R,O'Neill, C,Sharp, L
2014
September
Irish Journal Of Medical Science
The number of tPSA tests continues to rise and variation in testing practices persists: a survey of laboratory services in Ireland 2008-2010
Published
WOS: 6 ()
Optional Fields
PSA Laboratory survey Prostate cancer Decision-making Biopsy Costs PROSTATE-SPECIFIC ANTIGEN REFERENCE RANGES PSA CANCER MEN SERUM ESTABLISHMENT GUIDELINES COUNTRY LEVEL
183
369
375
Ireland had the highest incidence of prostate cancer in Europe in 2008, due to widespread prostate specific antigen (PSA) testing.To investigate practices and costs of PSA testing in Ireland, 2008-2010.Postal laboratory questionnaire. Results were compared with 2006 and 2007 surveys.Response rate was 95 % (42/44). In 2010, 37 laboratories measured total PSA (tPSA); 10 measured free PSA (fPSA). Eight assays were used and cut-offs to define 'normal' tPSA varied widely. There was a 9.9 % annual increase in the number of tPSA tests and a -31 % annual decrease in the number of fPSA, 2006-2010. A 100-fold difference in tPSA workload was observed across laboratories. In 2010, the estimated cost of PSA testing was a,not sign3,649,984 (95 % CI a,not sign2,532,745-a,not sign4,767,222).Health service costs of PSA testing are significant. The number of tPSA tests continues to rise; fPSA use fell by almost one-third. Inter-laboratory variation in testing practices persists. These have potentially important clinical consequences for men and need to be addressed.
10.1007/s11845-013-1022-y
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