Peer-Reviewed Journal Details
Mandatory Fields
Zhernovaya, O,Tuchin, VV,Leahy, MJ
Journal Of Biomedical Optics
Blood optical clearing studied by optical coherence tomography
Optional Fields
optical coherence tomography optical clearing blood SKIN SCATTERING AGGREGATION DEXTRAN RETINA IMAGES AGENTS INDEX MEDIA
The main limitation of optical imaging techniques for studying biological tissues is light scattering leading to decreasing of transmittance, which lowers the imaging quality. In this case, an immersion method for optical clearing of biological tissues can provide a possible solution to this problem, because the application of biocompatible clearing agents can reduce light scattering. Optical clearing represents a promising approach to increasing the imaging depth for various techniques, for example, various spectroscopy and fluorescent methods, and optical coherence tomography (OCT). We investigate the improvement of light penetration depth in blood after application of polyethylene glycol, polypropylene glycol, propylene glycol, and hemoglobin solutions using an OCT system. Influence of clearing agents on light transport in tissues and blood was also investigated in the mouse tail vein. (C) 2013 Society of Photo-Optical Instrumentation Engineers (SPIE) [DOI: 10.1117/1.JBO.18.2.026014]
Grant Details
Publication Themes