Peer-Reviewed Journal Details
Mandatory Fields
Deegan, S,Saveljeva, S,Gupta, S,MacDonald, DC,Samali, A
2014
August
Biochemical And Biophysical Research Communications
ER stress responses in the absence of apoptosome: A comparative study in CASP9 proficient vs deficient mouse embryonic fibroblasts
Published
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Optional Fields
Endoplasmic reticulum (ER) stress Apoptosis Autophagy Unfolded protein response (UPR) Caspase ENDOPLASMIC-RETICULUM STRESS CELL-DEATH AUTOPHAGY PROTEIN ACTIVATION CLEAVAGE KINASES PATHWAY
451
367
373
Cells respond to endoplasmic reticulum (ER) stress through the unfolded protein response (UPR), autophagy and cell death. In this study we utilized casp9(+/+) and casp9(-/-) MEFs to determine the effect of inhibition of mitochondrial apoptosis pathway on ER stress-induced-cell death, UPR and autophagy. We observed prolonged activation of UPR and autophagy in casp9(-/-) cells as compared with casp9(+/+) MEFs, which displayed transient activation of both pathways. Furthermore we showed that while casp9(-/-) MEFs were resistant to ER stress, prolonged exposure led to the activation of a non-canonical, caspase-mediated mode of cell death. (C) 2014 Elsevier Inc. All rights reserved.
10.1016/j.bbrc.2014.07.111
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