Peer-Reviewed Journal Details
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Tabrizi, L., McArdle, P., Erxleben, A., Chiniforoshan, H.
2015
November
Inorganica Chimica Acta
Cytotoxicity and antimicrobial activity of triorganotin(IV) complexes of phenylcyanamide prepared by sonochemical synthesis
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Triorganotin phenylcyanamide DNA binding BSA binding Antioxidant activity Cytotoxicity TRIDENTATE SCHIFF-BASE DNA-BINDING PROPERTIES IN-VITRO CYTOTOXICITY SN-119 NMR-SPECTRA X-RAY-DIFFRACTION STATE C-13 NMR SN-ME ANGLE CRYSTAL-STRUCTURE STRUCTURAL-CHARACTERIZATION DIORGANOTIN(IV) DERIVATIVES
438
94
104
This article describes the synthesis and characterization of novel triorganotin(IV) complexes and their potential medicinal applications. Triorganotin(IV) complexes with formulas [(SnMe3)(2)(mu-bp)(H2O)(2)], 1, and [(SnMe3)(4-NO(2)pcyd)], 2, (Me: methyl, bpH(2): 4,4'-dicyanamidobiphenyl and 4-NO(2)pcyd: 4-nitrophenylcyanamide) have been synthesized via a sonochemical process and characterized using multinuclear NMR (H-1, C-13 and Sn-119), Mossbauer spectroscopy, elemental analysis, scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Compounds 1 and 2 were evaluated for their DNA/protein binding with calf thymus DNA (CT-DNA) and bovine serum albumin (BSA), respectively. The in vitro cytotoxicity of 1 and 2 was examined against A549, Du145, HeLa and MCF-7 cancer cell lines. For 1, a promising growth inhibitory effect against HeLa cells was observed that is slightly higher than that of cisplatin. Moreover, the antimicrobial activity of 1 and 2 against different strains of pathogenic bacteria and fungi were tested. The free radical scavenging ability (OH, NO) of 1 and 2 was assessed. (C) 2015 Elsevier B.V. All rights reserved.
10.1016/j.ica.2015.09.011
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