Peer-Reviewed Journal Details
Mandatory Fields
Tabrizi, L., McArdle, P., Erxleben, A., Chiniforoshan, H.
2015
October
European Journal Of Medicinal Chemistry
Nickel(II) and cobalt(II) complexes of lidocaine: Synthesis, structure and comparative in vitro evaluations of biological perspectives
Published
WOS: 26 ()
Optional Fields
Lidocaine Cobalt(II) complexes Nickel(II) complexes DNA binding DNA cleavage BSA binding Cytotoxicity BOVINE SERUM-ALBUMIN DNA-BINDING PROPERTIES SCHIFF-BASE COMPLEXES CALF THYMUS DNA MAGNETIC-PROPERTIES CRYSTAL-STRUCTURE INTRAVENOUS LIDOCAINE NEUROPATHIC PAIN ANTIMICROBIAL ACTIVITY COORDINATION POLYMER
103
516
529
Metal complexes of the type [Ni(LC)(2)(X)(2)], 1 and 2, [Co(LC)(2)(X)(2)], 3 and 4 (LC: lidocaine, X = dca (dicyanamide), 1 and 3, X = NCS-, 2 and 4) have been synthesized and characterized. The geometries of 1 -4 were confirmed by single crystal X-ray crystallography. The complexes are water soluble and stable in aqueous solution. The interaction of 1-4 with calf thymus. DNA (CF DNA) and bovine serum albumin (BSA) was investigated using UV-visible and fluorescence spectrophotometric methods. A gel electrophoresis assay demonstrated that the complexes cleave pUC19 plasmid DNA. The in vitro free radical scavenging, antimicrobial activity and cytotoxic potential of all the complexes were examined. (C) 2015 Elsevier Masson SAS. All rights reserved.
10.1016/j.ejmech.2015.09.018
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