Peer-Reviewed Journal Details
Mandatory Fields
Fernandez-Yague, MA,Larranaga, A,Gladkovskaya, O,Stanley, A,Tadayyon, G,Guo, YN,Sarasua, JR,Tofail, SAM,Zeugolis, DI,Pandit, A,Biggs, MJ
2015
October
Bioconjugate Chemistry
Effects of Polydopamine Functionalization on Boron Nitride Nanotube Dispersion and Cytocompatibility
Published
()
Optional Fields
WALLED CARBON NANOTUBES HUMAN ENDOTHELIAL-CELLS IN-VITRO GLYCOL-CHITOSAN PURIFICATION ULTRASONICATION IMMOBILIZATION NANOCOMPOSITES NANOPARTICLES BIOMATERIALS
26
2025
2037
Boron nitride nanotubes (BNNTs) have unique physical properties, of value in biomedical applications; however, their dispersion and functionalization represent a critical challenge in their successful employment as biomaterials. In the present study, we report a process for the efficient disentanglement of BNNTs via a dual surfactant/polydopamine (PD) process. High-resolution transmission electron microscopy (HR-TEM) indicated that individual BNNTs become coated with a uniform PD nanocoating, which significantly enhanced dispersion of BNNTs in aqueous solutions. Furthermore, the cytocompatibility of PD-coated BNNTs was assessed in vitro with cultured human osteoblasts (HOBs) at concentrations of 1, 10, and 30 mu g/mL and over three time-points (24, 48, and 72 h). In this study it was demonstrated that PD-functionalized BNNTs become individually localized within the cytoplasm by endosomal escape and that concentrations of up to 30 mu g/mL of PD-BNNTs were cytocompatible in HOBs cells following 72 h of exposure.
10.1021/acs.bioconjchem.5b00257
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